Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens.
Identifieur interne : 000042 ( Main/Exploration ); précédent : 000041; suivant : 000043Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens.
Auteurs : Raphael Weinberger [Allemagne] ; Marion Riffelmann [Allemagne] ; Nicole Kennerknecht [Allemagne] ; Christel Hül E [Allemagne] ; Martina Littmann [Allemagne] ; Judith O'Brien [Allemagne] ; Rüdiger Von Kries [Allemagne] ; Carl Heinz Wirsing Von König [Allemagne]Source :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Anticorps antibactériens (sang), Anticorps antiviraux (sang), Bactéries (immunologie), Bactéries (isolement et purification), Estimation de Kaplan-Meier (MeSH), Femelle (MeSH), Fumer (épidémiologie), Humains (MeSH), Incidence (MeSH), Infections bactériennes (microbiologie), Infections bactériennes (épidémiologie), Jeune adulte (MeSH), Maladie chronique (MeSH), Maladies virales (virologie), Maladies virales (épidémiologie), Mâle (MeSH), Partie nasale du pharynx (microbiologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Toux (microbiologie), Toux (virologie), Toux (épidémiologie), Virus (immunologie), Virus (isolement et purification), Études de cohortes (MeSH).
- MESH :
- immunologie : Bactéries, Virus.
- isolement et purification : Bactéries, Virus.
- microbiologie : Infections bactériennes, Partie nasale du pharynx, Toux.
- sang : Anticorps antibactériens, Anticorps antiviraux.
- virologie : Maladies virales, Toux.
- épidémiologie : Allemagne, Fumer, Infections bactériennes, Maladies virales, Toux.
- Adolescent, Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Incidence, Jeune adulte, Maladie chronique, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antibodies, Bacterial (blood), Antibodies, Viral (blood), Bacteria (immunology), Bacteria (isolation & purification), Bacterial Infections (epidemiology), Bacterial Infections (microbiology), Chronic Disease (MeSH), Cohort Studies (MeSH), Cough (epidemiology), Cough (microbiology), Cough (virology), Female (MeSH), Germany (epidemiology), Humans (MeSH), Incidence (MeSH), Kaplan-Meier Estimate (MeSH), Male (MeSH), Middle Aged (MeSH), Nasopharynx (microbiology), Smoking (epidemiology), Virus Diseases (epidemiology), Virus Diseases (virology), Viruses (immunology), Viruses (isolation & purification), Young Adult (MeSH).
- MESH :
- chemical , blood : Antibodies, Bacterial, Antibodies, Viral.
- epidemiology : Bacterial Infections, Cough, Germany, Smoking, Virus Diseases.
- immunology : Bacteria, Viruses.
- isolation & purification : Bacteria, Viruses.
- microbiology : Bacterial Infections, Cough, Nasopharynx.
- virology : Cough, Virus Diseases.
- Adolescent, Adult, Aged, Aged, 80 and over, Chronic Disease, Cohort Studies, Female, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Young Adult.
Abstract
Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.
DOI: 10.1007/s10096-017-3158-6
PubMed: 29302815
PubMed Central: PMC7088169
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor: Medizin Krefeld MVZ GmbH, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Von Kries, Rudiger" sort="Von Kries, Rudiger" uniqKey="Von Kries R" first="Rüdiger" last="Von Kries">Rüdiger Von Kries</name><affiliation wicri:level="3"><nlm:affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation><country 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xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Riffelmann, Marion" sort="Riffelmann, Marion" uniqKey="Riffelmann M" first="Marion" last="Riffelmann">Marion Riffelmann</name><affiliation wicri:level="1"><nlm:affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor: Medizin Krefeld MVZ GmbH, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation></author><author><name sortKey="Kennerknecht, Nicole" sort="Kennerknecht, Nicole" uniqKey="Kennerknecht N" first="Nicole" last="Kennerknecht">Nicole Kennerknecht</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation></author><author><name sortKey="Hul E, Christel" sort="Hul E, Christel" uniqKey="Hul E C" first="Christel" last="Hül E">Christel Hül E</name><affiliation wicri:level="1"><nlm:affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Littmann, Martina" sort="Littmann, Martina" uniqKey="Littmann M" first="Martina" last="Littmann">Martina Littmann</name><affiliation wicri:level="1"><nlm:affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, Judith" sort="O Brien, Judith" uniqKey="O Brien J" first="Judith" last="O'Brien">Judith O'Brien</name><affiliation wicri:level="3"><nlm:affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor: Medizin Krefeld MVZ GmbH, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Von Kries, Rudiger" sort="Von Kries, Rudiger" uniqKey="Von Kries R" first="Rüdiger" last="Von Kries">Rüdiger Von Kries</name><affiliation wicri:level="3"><nlm:affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Von Konig, Carl Heinz Wirsing" sort="Von Konig, Carl Heinz Wirsing" uniqKey="Von Konig C" first="Carl Heinz Wirsing" last="Von König">Carl Heinz Wirsing Von König</name><affiliation wicri:level="1"><nlm:affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany. chwvk@gmx.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor: Medizin Krefeld MVZ GmbH, Krefeld</wicri:regionArea><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion><wicri:noRegion>Krefeld</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="eISSN">1435-4373</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Antibodies, Bacterial (blood)</term><term>Antibodies, Viral (blood)</term><term>Bacteria (immunology)</term><term>Bacteria (isolation & purification)</term><term>Bacterial Infections (epidemiology)</term><term>Bacterial Infections (microbiology)</term><term>Chronic Disease (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Cough (epidemiology)</term><term>Cough (microbiology)</term><term>Cough (virology)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Humans (MeSH)</term><term>Incidence (MeSH)</term><term>Kaplan-Meier Estimate (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Nasopharynx (microbiology)</term><term>Smoking (epidemiology)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (virology)</term><term>Viruses (immunology)</term><term>Viruses (isolation & purification)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Anticorps antibactériens (sang)</term><term>Anticorps antiviraux (sang)</term><term>Bactéries (immunologie)</term><term>Bactéries (isolement et purification)</term><term>Estimation de Kaplan-Meier (MeSH)</term><term>Femelle (MeSH)</term><term>Fumer (épidémiologie)</term><term>Humains (MeSH)</term><term>Incidence (MeSH)</term><term>Infections bactériennes (microbiologie)</term><term>Infections bactériennes (épidémiologie)</term><term>Jeune adulte (MeSH)</term><term>Maladie chronique (MeSH)</term><term>Maladies virales (virologie)</term><term>Maladies virales (épidémiologie)</term><term>Mâle (MeSH)</term><term>Partie nasale du pharynx (microbiologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Toux (microbiologie)</term><term>Toux (virologie)</term><term>Toux (épidémiologie)</term><term>Virus (immunologie)</term><term>Virus (isolement et purification)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Bacterial</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bacterial Infections</term><term>Cough</term><term>Germany</term><term>Smoking</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Bactéries</term><term>Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bacteria</term><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term><term>Virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections bactériennes</term><term>Partie nasale du pharynx</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacterial Infections</term><term>Cough</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antibactériens</term><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies virales</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cough</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Fumer</term><term>Infections bactériennes</term><term>Maladies virales</term><term>Toux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chronic Disease</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Maladie chronique</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29302815</PMID><DateCompleted><Year>2018</Year><Month>08</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-4373</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>Apr</Month></PubDate></JournalIssue><Title>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</Title><ISOAbbreviation>Eur. J. Clin. Microbiol. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens.</ArticleTitle><Pagination><MedlinePgn>665-672</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10096-017-3158-6</ELocationID><Abstract><AbstractText>Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weinberger</LastName><ForeName>Raphael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riffelmann</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennerknecht</LastName><ForeName>Nicole</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hülße</LastName><ForeName>Christel</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Littmann</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Brien</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Landesamt für Gesundheit und Soziales des Landes Mecklenburg Vorpommern, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Kries</LastName><ForeName>Rüdiger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institut für Soziale Pädiatrie, Ludwig-Maximilians-Universität, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von König</LastName><ForeName>Carl Heinz Wirsing</ForeName><Initials>CHW</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1914-013X</Identifier><AffiliationInfo><Affiliation>Labor: Medizin Krefeld MVZ GmbH, Krefeld, Germany. chwvk@gmx.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Clin Microbiol Infect Dis</MedlineTA><NlmUniqueID>8804297</NlmUniqueID><ISSNLinking>0934-9723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000907" MajorTopicYN="N">Antibodies, Bacterial</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003371" MajorTopicYN="Y">Cough</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053208" MajorTopicYN="N">Kaplan-Meier Estimate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>8</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29302815</ArticleId><ArticleId 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name="Bavière"><name sortKey="Weinberger, Raphael" sort="Weinberger, Raphael" uniqKey="Weinberger R" first="Raphael" last="Weinberger">Raphael Weinberger</name></region><name sortKey="Hul E, Christel" sort="Hul E, Christel" uniqKey="Hul E C" first="Christel" last="Hül E">Christel Hül E</name><name sortKey="Kennerknecht, Nicole" sort="Kennerknecht, Nicole" uniqKey="Kennerknecht N" first="Nicole" last="Kennerknecht">Nicole Kennerknecht</name><name sortKey="Littmann, Martina" sort="Littmann, Martina" uniqKey="Littmann M" first="Martina" last="Littmann">Martina Littmann</name><name sortKey="O Brien, Judith" sort="O Brien, Judith" uniqKey="O Brien J" first="Judith" last="O'Brien">Judith O'Brien</name><name sortKey="O Brien, Judith" sort="O Brien, Judith" uniqKey="O Brien J" first="Judith" last="O'Brien">Judith O'Brien</name><name sortKey="O Brien, Judith" sort="O Brien, Judith" uniqKey="O Brien J" first="Judith" last="O'Brien">Judith O'Brien</name><name sortKey="O Brien, Judith" sort="O Brien, Judith" uniqKey="O Brien J" first="Judith" last="O'Brien">Judith O'Brien</name><name sortKey="Riffelmann, Marion" sort="Riffelmann, Marion" uniqKey="Riffelmann M" first="Marion" last="Riffelmann">Marion Riffelmann</name><name sortKey="Riffelmann, Marion" sort="Riffelmann, Marion" uniqKey="Riffelmann M" first="Marion" last="Riffelmann">Marion Riffelmann</name><name sortKey="Von Konig, Carl Heinz Wirsing" sort="Von Konig, Carl Heinz Wirsing" uniqKey="Von Konig C" first="Carl Heinz Wirsing" last="Von König">Carl Heinz Wirsing Von König</name><name sortKey="Von Kries, Rudiger" sort="Von Kries, Rudiger" uniqKey="Von Kries R" first="Rüdiger" last="Von Kries">Rüdiger Von Kries</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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